Only very low quality evidence available on the use of platelets for jawbone defects

Teeth are maintained in their position by soft and hard tissues (gums and surrounding bone). Gum disease or periodontitis, is an inflammatory condition of all these tissues caused by the bacteria present in the dental plaque. If left untreated, gum disease can cause teeth to loosen and eventually lead to tooth loss. The destruction of jaw bone around teeth (called the alveolar bone) during gum disease, can be horizontal (where the whole level of bone around the root is reduced) or vertical, forming a bone defect within the bone (infrabony defect). There are several available surgical treatments for infrabony defects, including: 1. open flap debridement in which the gum is lifted back surgically in order to clean the deep tartar; 2. bone graft in which a portion of natural or synthetic bone is placed in the area of bone loss; 3. guided tissue regeneration in which a small piece of membrane-like material is placed between the bone and gum tissue in order to keep the gum tissue from growing into the area where the bone should be; and 4. the use of enamel matrix derivative, a gel-like material which is placed in the area where bone loss has occurred and promotes its regeneration. In order to accelerate the healing process, autologous platelet concentrates have been recently used. They are concentrates of the platelets of patient’s own blood containing growth factors that are thought to promote tissue regeneration. The aim of this review was to assess if the addition of APC brings any benefits in the treatment of infrabony defects when combined with different surgical treatments. Continue reading

Three new titles registered by the Oral Health Group

acupuncture needles

Acupuncture is one of the options for preventing gag reflex, but how effective is it compared to other interventions? A new Cochrane review will consider the evidence. Photo published under GNU Free Documentation License.

The Cochrane Oral Health Group‘s editorial team met last week to consider which new titles to register. OHG have had a number of submissions over the last six months, and three titles have been registered by the Group. The editors identified them as priority topics, and agreed that they did not significantly overlap with any existing reviews:

Interventions for the prevention of osteoradionecrosis of the jaws in patients receiving head and neck radiotherapy

This review will be led by Dr. Amri Azarpazhooh from the University of Toronto in Canada. He will be joined on the team by Dr. Michael Duchnay, Dr. Grace Bradley, Dr. Howard Tenenbaum, Dr. Prakeshkumar S. Shah and Dr. Hamid Reza Raziee, who are all also based at the University of Toronto.

Prevention of gag reflex for patients undergoing dental treatment

Dr. Eachempati Prashanti from Melaka-Manipal Medical College in Malaysia will lead this new review. Dr. P. Renjith George, Professor Nagraj Sumanth Kumargere, Dr. Laxminarayan Karanth and Dr. Htoo Htoo Kyaw Soe will also be on the on the author team.

Autologous platelet concentrates for regeneration of periodontal defects

This review will be a collaboration between authors based in Italy and India. Dr. Massimo Del Fabbro from Università degli Studi di Milano leads the team, his colleagues Dr. Valentina Ceresoli and Dr. Caterina Ceci will join him as authors. Dr. Silvio Taschieri from University of Milan IRCCS Galazzi Orthopaedic Institute is also an author. The author team is completed by Dr. Saurav Panda, Professor Sheeja Varghese, Professor Malaiappa Sankari, Professor N. D. Jayakumar and Dr. Surenda Ramamoorthi from Saveetha University, India.

We look forward to publishing the protocols in the near future, watch this space!